Bolus for oral administration

Composition:

Each tablet contains:

Niclosamide piperazine salt : 1250mg

Capacity：10boluses/blister, 10blister/box

Description

Niclosamide Bolus inhibits phosphorylation in the mitochondria of cestodes. Both in vitro and in vivo, the scolex and proximal segments are killed on contact with the drug. The loosened scolex may be digested in the intestine; hence, it may be impossible to identify the scolex in the faeces. Niclosamide Bolus is taenicidal in action and eliminates not only the segments but also scolex.

Niclosamide Bolus activity against the worms appears to be due to inhibition of mitochondrial oxidative phosphorylation; anaerobic ATP production is also affected.

The cestocidal activity of Niclosamide Bolus is due to the inhibition of absorbtion of glucose by the tapeworm and to the uncoupling of the oxidative phosphorylation process in the mitochondria of cestodes. The accumulated lactic acid resulting from the blocking of Krebs cycle kills the worms.

Indications

Niclosamide Bolus is indicated in both tapeworm infestation of Livestock, Poultry, Dogs and Cats and also in immature paramphistomiasis (Amphistomiasis) of Cattle, Sheep and Goats.

Tapeworms

Cattle, Sheep Goats and Deer: Moniezia Species Thysanosoma (Fringed Tape worms)

Dogs: Dipylidium Caninum, Taenia Pisiformis T. hydatigena and T. taeniaeformis.

Horses: Anoplocephalid infections

Poultry: Raillietina and Davainea

Amphistomiasis: (Immature Paramphistomes)

In cattle and Sheep, Rumen flukes (Paramphistomum species) is very common. Whereas the adult flukes attached to the rumen wall could be of little significance, the immature ones are seriously pathogenic causing heavy damage and mortality while migrating in the duodenal wall.

Animals showing symptoms of severe anorexia, increased intake of water, and watery fetid diarrhoea should be suspected for amphistomiasis and immediately treated with Niclosamide Bolus to prevent death and loss of production since Niclosamide Bolus provides consistently very high efficacy against the immature flukes.

Administration And Dosage

By oral administration:

Sheep and Goats : 75–80 mg of Niclosamide per kg Bodyweight or one bolus for 15 kg Bodyweight.

Cattle : 60–65 mg of Niclosamide per kg Bodyweight or one bolus for 20 kg Bodyweight

Dogs : 125 mg of Niclosamide per kg Bodyweight or one bolus for 10 kg Bodyweight

Cats : 125 mg of Niclosamide per kg Bodyweight or 1/3 bolus for 3.3 kg Bodyweight

Withdrawal Times

Sheep : 28days.

Cattle : 28days.

Storage

Store in a cool place. Protect from light

Keep out of reach of children.