Enterprise passed GMP certification of veterinary medicine

Veterinary drug GMP Certificate Number: (2022) Veterinary drug GMP Certificate number 15049 

Veterinary drug production Certificate Number: (2022) Veterinary drug production Certificate number 15318 

Instructions For Flunixin Meglumine Injection （OTC drugs for veterinary use）

【Veterinary Drug Name】 

Product Name: Flunixin Meglumine Injection

Chinese Pinyin: Funixin Pujia，an Zhusheye

【Main ingredient】Flunixin Meglumine

【Characters】This product is colorless or light yellow clear liquid

【Pharmacological actions】

Pharmacodynamics ：Flunixin glucosamine is a potent cyclooxygenase inhibitor with analgesic, antipyretic, anti-inflammatory and

antirheumatic effects. The analgesic effect is caused by the inhibition of peripheral synthesis of prostaglandins or their nociceptive sensitisers or their combined action, thus blocking the transmission of nociceptive impulses.

The analgesic effect is caused by inhibiting the synthesis of prostaglandins or their nociceptive sensitisers in the periphery or their combined action, thus blocking the transmission of nociceptive impulses. The anti-inflammatory effect in peripheral tissues may be mediated by inhibition of cyclooxygenase, reduction of prostaglandin precursor substance formation, and

The anti-inflammatory effect in peripheral tissues may be due to inhibition of cyclooxygenase, reduction of prostaglandin precursor formation, and inhibition of other mediators of local inflammatory reactions

Pharmacokinetics ：After administration of a single intramuscular injection in pigs (2.2 mg/kg body weight), the plasma elimination half-life was 3-4 hours, the peak concentration was 2.94 μg/ml, the time to peak was 0.4 hours, and the drug could still be detected in the blood 18 hours after administration. The apparent volume of distribution was 2.0 L/kg and the bioavailability was 87% for a single neck injection.

【Drug interaction】

(1)Don’t use flunixin meglumine together with other non-steroidal anti-inflammatory drugs, because it will aggravate the toxic side effects on the gastrointestinal tract, such as ulceration and bleeding.

(2)Due to high plasma protein binding rate, when used in combination with other drugs, flunixin meglumine may displace other drugs bound to plasma proteins or be displaced by other drugs, resulting in enhanced effects of the displaced drug or even toxicity. 

(3)Combined with antibiotics, it is used for the auxiliary treatment of lactation-free syndrome in sows.

【Function and use】Antipyretic, analgesic and anti-inflammatory drugs. For livestock and small animals fever, inflammatory diseases, muscle pain and soft tissue pain.

【Usage and dosage】Intramuscular and intravenous injection: one dose, per 10kg weight, 0.4ml for beef cattle and livestocks; 0.2~0.4ml for dogs and cats.1~2 times a day, not more than 5 days in a row.

【Adverse reactions】Intramuscular injection is locally irritating. Prolonged use of this product in high doses may result in gastric ulcers and renal impairment in animals.

【Cautions】Use with caution in animals with peptic ulcers

【Drug withdrawal period】Cow, swine 28 days.

【Specification】according to C14H11F3N2O2 100ml：5g

【Package 】100ml/ bottle

【Storage 】 Dark, sealed storage.

【Approval number】Veterinary Medicine 153182102

【Batch number】

【Production date】

【Validity until 】