GMP acceptance of veterinary drugs passed the enterprise

Veterinary drug GMP Certificate Number:  (2022) Veterinary drug GMP Certificate number 15049

Veterinary drug production Certificate Number:  (2022) Veterinary drug production Certificate number 15318

Instructions For Ivermectin Injection (OTC drugs for veterinary use)

【Veterinary drug name】

Product Name: Ivermectin Injection

Chinese Pinyin: Yiweijunsu Zhusheye

【 Main ingredient 】 Ivermectin

【Characters】This product is colorless or almost colorless clear liquid, slightly viscous.

Pharmacodynamics Ivermectin mainly has a good repellant effect on nematodes and surface arthropods in vivo. The mechanism of its repellent action is to promote the release of gamma-aminobutyric acid (GABA) from presynaptic neurons, thus opening GABA-mediated chloride ion channels. Ivermectin also has selectivity and high affinity for glutamate-mediated chloride ion channels located near GABA-mediated sites in invertebrate nerve and muscle cells, thus interfering with neuromuscular signal transmission, relaxing and paralysing the worm body, leading to death or expulsion of the worm body. Inhibitory interneurons and excitatory motor neurons are the sites of action in nematodes, while the sites of action in arthropods are neuromuscular junctions. The elimination rate of Hemonchodes, Osteria, Cuprea, Trichostrongylus (including Trichostrongylus Ehrsoni), Strongylus, obliquis, plectoceris, Trichocephalus, oesophagostoma, dictyocurca, and adult and fourth stage larvae of Chabot in sheep and cattle was 97% ~ 100%. It is also effective against arthropods such as maggots, mites and lice. It is slightly less effective against lice chewing and sheep tick flies. Ivermectin is also extremely effective against ticks and flies that breed in their faeces. Although the drug does not kill ticks immediately, it can affect feeding, molting and laying eggs, thereby reducing reproductive ability. The effect on blood flies is similar. The elimination rate of Ascaris, Strongyloides rubrosuis, Strongyloides lamberti, Trichocephalus, oesophagostoma, posterior strongyloides, Coryneus dentatus and immature worm bodies in pigs was 94% to 100%, and it was also very effective against trichinus spiralis in the intestine (but not trichinus spiralis in the muscles), and it also had a good control effect on blood louse and Sarcoptes suis. Not effective against flukes and tapeworms.

The pharmacokinetics of ivermectin vary significantly with different animal species, dosage forms and routes of administration. The bioavailability of subcutaneous injection is higher than that of oral administration, but oral administration is more rapidly absorbed than subcutaneous injection. After absorption, it can be well distributed to most tissues, but it is not easy to enter cerebrospinal fluid. The apparent volume of distribution of cattle, sheep and pigs was 0.45 ~ 2.4L/kg, 4.6L/kg and 4L/kg, respectively. Most animals have long half-lives, 2 to 3 days for cattle, 2 to 7 days for sheep and 0.5 days for pigs. This product is metabolized in the liver, mainly hydroxylated in cattle and sheep, and mainly methylated in pigs. It is mainly excreted from feces, and less than 5% is excreted in the urine as the original form prototype or metabolite In lactating females up to 5% of the administered dose is excreted from the milk.

【Drug interaction】When used together with ethazine, serious or fatal encephalopathy may occur.  

【Function and use】 Macrolide antiparasitic drugs. It is used for preventing and treating livestock nematodiasis, acariasis and other parasitic insect diseases.

【Usage and dosage】 Subcutaneous injection: one dose, 0.02ml per 1kg body weight in cattle and sheep; Pig 0.03ml.

【Adverse reactions】

(1)When used for the treatment of bovine dermatomycosis, if the larvae are killed in key parts, it will cause serious adverse reactions.

(2) Discomfort or temporary edema at the injection site during injection.

【Precautions】

(1)Cows and sheep that produce milk for human consumption shall not be used during lactation.

(2)Each subcutaneous injection sitepoint should not exceed 10mL.

(3)Ivermectin is highly toxic to shrimp, fish and aquatic organisms, and the remaining drugs and packaging should not pollute the water source.

【Drug withdrawal period】Cattle, sheep 35 days, pig 28 days.

【Specification】100ml: 1000mg according to ivermectin (H2B1a+H2B1b)

【 Package 】100ml/ bottle

【 Storage 】 Dark, airtight, stored in a dry place.

【Approval number】Veterinary drug 153181128

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